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Olympus
Engaged
Nothing in that list looks particularly strange to me, although this one stands out a bit to me:
O4 - HKCU\..\Run: [Tune-In] C:\Documents and Settings\Lenovo Laptop\Local Settings\Apps\2.0\OEJ65BWN.0YG\62VG1GXR.HZT\tune..tion_f3b813443c99b721_0000.0000_44bbadfe12e50c96\tune-in.exe
I'm not sure exactly what that one is, but it's set to run on startup. He could try renaming it to something like "tune-in.exe.org" and restart, to see if it helps. Also, does he have anything in his DVD drive(s)? Maybe his PowerDVD app is doing kooky things and playing stuff off of it unexpectedly.